An inscription or epigraph is generally the name given to inscriptions on a monumental work for promotional and informative purposes. Inscriptions are of primary importance in terms of historical material. Inscriptions are important first in terms of cultural history and then in terms of showing who made them and why. The motifs on the stone on which the inscription is carved are important in terms of art history. Inscriptions are also silent witnesses of history. Studies and publications were made on Arabic and Ottoman inscriptions in Şanlıurfa . This study, which was completed in 25 years, is a first in its field in the history of Urfa. No such scientific publication has been made on this subject before. However, Western scientists have published many books and articles on the Greek and Syriac inscriptions they found in Urfa. The inscriptions left by the societies that have dominated Şanlıurfa over a historical period of approximately 2000 years and that have survived to the present day were photographed or transcribed and translated, and an attempt was made to shed light on the history of the region. This book, which examines a total of 134 inscriptions, 16 in Greek, 12 in Armenian and 106 in Syriac, will make a great contribution especially to those who will research the history and culture of the region. As for the classification of the inscriptions; it is possible to separate them as tomb, mosaic, karlık, memorial and construction inscriptions. By entering the mystery and world of these inscriptions that will shed light on the history of our region, you will also get to know our culture and history. Inscriptions will continue to be written as long as humanity and civilization live.